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WHAT'S NEW IN TUBERCULOSIS

Friday 21 September 2007

Moxifloxacin vs Isoniazid

Moxifloxacin performed as well as isoniazid in treating pulmonary tuberculosis (TB) in a multinational phase. Subjects were randomized to receive 400 mg/day of moxifloxacin or 300 mg/day isoniazid, given 5 days per week for 8 weeks. All patients also were treated with rifampin, ethambutol and pyrazinamide on the same schedule. The primary measure of treatment success was two consecutive sputum cultures negative for TB organisms. Time to first negative culture was a secondary endpoint. Based on earlier clinical studies, the investigators were hoping to see a treatment success rate of 88% among moxifloxacin patients completing the study protocol. The differences between drugs were not significant.
http://tinyurl.com/2s8qv

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