TUBERCULOSIS IN CHILDREN

http://www.medindia.net/news/Tuberculosis-Control-Efforts-Must-Include-Kids-40822-1.htm
William Burman from the Denver Public Health and the University of Colorado Health Sciences Center, Denver, USA, and colleagues said that kids are an often ignored but important part of tuberculosis control efforts. In high-burden settings, children make up as much as 20 percent of new cases of active tuberculosis. Young children are also at high risk of having severe, rapidly progressive forms of tuberculosis. However, nearly 40 years after the development of short-course treatments in adults, there are still major uncertainties about dosing for children of common TB drugs. "Only in recent years has there been a substantial effort to manufacture child-friendly formulations of first-line tuberculosis drugs (such as crushable mini-pills, granules, oral suspensions)," the researchers said. "And in the past 15 years, children have been included in only one study of new agents for tuberculosis: a large Phase 3 trial evaluating once-weekly rifapentine + isoniazid for treatment of latent tuberculosis," they added. The researchers said that including children in drug development is especially critical, as the two main threats to tuberculosis control, HIV-related immunodeficiency and drug-resistant tuberculosis, challenge our ability to develop effective drug regimens. Burman and colleagues outline several traditional barriers to the involvement of children in tuberculosis drug development such as difficulty confirming TB diagnosis, concern about side effects, and regulatory requirements.